D-Mannose UTI Cleanse (50grams) item#3 | |
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" D-Mannose." | CANADIAN $29.99
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| A.O.R. D-Mannose. D-Mannose offers a safe, natural option with a simple, ingenious rationale, no known side-effects, and a great reported success rate for urinary tract infections; without dangerous side-effect-inducing antibiotics .
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" for more info visit www.aor.ca" | Features:
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50g Powder 100% Vegetarian
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Each ˝ Teaspoon Contains :D-Mannose ~1.1g
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Suggested Use:
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.....................Take ˝ to 1 teaspoon (~1.1 to 2.5g) of D-Mannose in water every 3 to 4 hours, or as directed by a qualified health care practitioner.
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Main Applications:•Urinary tract infection.
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Related Research of D-Mannose
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Although urinary tract infections (UTIs) can involve a variety of Enterobacteriaceae and Gram-positive pathogens (including Staphylococcus saprophyticus and some enterococci species)
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nearly all infections of the lower urinary tract and bladder are caused by a few strains of E. coli bacteria called uropathogenic
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Escherichia coli (UPEC). Various harmless strains of E. coli are normally present in the body – but they don’t belong in the urinary tract.
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If UPEC get into the bladder or the urethra, the body has ways of fighting them off – including the obvious method of simply flushing them out with the urine.
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But these bacteria have evolved ways of anchoring themselves to cells of the urinary tract. The invading UPEC take advantage of receptors naturally found on cells of the lining of the urinary tract.
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Receptors are like molecular "docking bays" for substances that the cells need for their normal growth and development.
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Like pirates in an old movie, UPEC use "grappling hooks" called type I pili to first hook on to these receptors, and then to invade the cell.
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Once inside the cell, these pathogens can live and reproduce in safety, shielded from many of the body’s defensive immune responses.
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Pathogenic E. coli bacteria’s pili "grappling hooks" are composed of long, fibrous chains of a molecular "glue" called adhesin.
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The effective binding of these adhesin molecules depends on the chemical attraction that exists between them
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and the residues of a simple carbohydrate called D-Mannose on the cell surface receptors of the urinary tract host cells.
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If you can interfere with the binding of adhesins to D-Mannose residues in the receptors of your urinary tract cells, then you can also prevent UPEC from getting a foothold for adherence & infection.
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One way to do this, is by using D-Mannose itself. The bacterial adhesins bind to the D-Mannose in their environment instead of to the D-Mannose residues on the cells.
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This gums up their pili and prevents them from hooking onto urinary tract cells helping the body flush them out in the urine.
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It was discovered in the late 1980s that a small amount of D-Mannose is present in the urine normally, apparently acting as a defensive mechanism against pathogenic bacteria.
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When D-Mannose is taken as a supplement, much more of the carbohydrate passes through the urinary tract, strengthening this natural defense.
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A decade after this discovery, Dr. Jonathan V. Wright of the Tahoma Clinic pioneered the use of D-Mannose supplements to fight off UTIs.
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For some years, he has been reporting the successful results that his patients have experienced in using D-Mannose to rid themselves of infection.
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Patients who remained infected after having been subjected to a wide range of potent, side-effect-inducing antibiotics have successfully rid themselves of chronic or acute infections using D-Mannose.
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Other nutritionally oriented physicians and health practitioners have since adopted Dr. Wright’s protocols
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Again, not all UTIs are caused by UPEC.
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. So if you try a course of D-Mannose and infection persists, it is likely not caused by these E. coli bacteria but by some other pathogen.
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In that case, don’t just keep going on with the supplement in hopes that it will eventually "kick in:"
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discontinue use of D-Mannose and consult a physician for treatment appropriate to your case.
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But for the great majority of urinary tract infections, D-Mannose offers a safe, natural option with a simple, ingenious rationale, no known side-effects, and a great reported success rate.
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References
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Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ. Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J. 2000 Jun 15; 19(12): 2803-12.
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Sauer FG, Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ. Bacterial pili: molecular mechanisms of pathogenesis.Curr Opin Microbiol. 2000 Feb; 3(1): 65-72.
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Toyota S, Fukushi Y, Katoh S, Orikasa S, Suzuki Y. Anti-bacterial defense mechanism of the urinary bladder. Role of mannose in urine. Nippon Hinyokika Gakkai Zasshi. 1989 Dec; 80(12): 1816-23.
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Wright JV. D-Mannose for bladder and kidney infections. Townsend Letter for Doctors and Patients. 1999 Jul; 192: 96-8.
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| Reference: | 04020 |
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| UPC code: | 04020 |
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| Size, Capacity: | 50grams |
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| Manufactured by: | A.O.R. |
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| Made in Canada |
| Payment Methods |
| MasterCard, Visa, Diners Club, American Express, PayPal, PayPal, certified cheques, money orders. Details call 1-888-249-0990 or 1-780-645-1181 International |
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